Cells which secrete histamine

J Immunol 8 — Mast cells: a unique source of renin. J Clin Invest 4 — Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells. Circulation 8 — Hartman J, Frishman WH. Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy.

Cardiol Rev 22 3 — Immune mechanisms in atherosclerosis. Arteriosclerosis 9 5 — Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med 5 — Innate and adaptive immunity in the pathogenesis of atherosclerosis.

Circ Res 91 4 — Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19 7 —9. Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation 18 —9. Kovanen PT. Role of mast cells in atherosclerosis. Chem Immunol 62 — Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice.

Circulation 19 — Association between myocardial infarction and the mast cells in the adventitia of the infarct-related coronary artery.

Circulation 99 3 —9. Innate immune system cells in atherosclerosis. Arch Med Res 45 1 :1— J Clin Invest 9 — Mast cells induce vascular smooth muscle cell apoptosis via a toll-like receptor 4 activation pathway. Arterioscler Thromb Vasc Biol 32 8 —9. PLoS One 8 4 :e Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation. Biochim Biophys Acta 5 — Cytokine production by mast cells and basophils.

Curr Opin Immunol 3 6 — Mast cells: important players in the orchestrated pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 31 4 — Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest 11 — Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm.

Circ Res 11 — Angiotensin-converting enzyme inhibitors and aortic rupture: a population-based case-control study. Lancet — Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors. J Vasc Surg 33 5 — Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol 2 — Mast cells as effectors in atherosclerosis.

Arterioscler Thromb Vasc Biol 35 2 — Neovascularization and coronary atherosclerotic plaque: cinematographic localization and quantitative histologic analysis. Hum Pathol 18 10 — Mast cells accompany microvessels in human coronary atheromas: implications for intimal neovascularization and hemorrhage. Atherosclerosis 1—2 — Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med 13 6 — Mast cell chymase induces smooth muscle cell apoptosis by a mechanism involving fibronectin degradation and disruption of focal adhesions.

Arterioscler Thromb Vasc Biol 23 2 — Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Exp Cell Res 8 — Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha.

Arterioscler Thromb Vasc Biol 28 2 — Low-density-lipoprotein binding by mast-cell granules. Demonstration of binding of apolipoprotein B to heparin proteoglycan of exocytosed granules. Biochem J 2 —9. Kokkonen JO. Stimulation of rat peritoneal mast cells enhances uptake of low density lipoproteins by rat peritoneal macrophages in vivo.

Atherosclerosis 79 2—3 — Levels of IgE in the serum of patients with coronary arterial disease. Int J Cardiol 31 2 — Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis. PLoS One 9 2 :e Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovasc Res 97 2 — Mast cell activation by lipoproteins. Methods Mol Biol —8.

Advanced glycation end products AGEs activate mast cells. Br J Pharmacol 2 — Substance P signaling controls mast cell activation, degranulation, and nociceptive sensitization in a rat fracture model of complex regional pain syndrome. Anesthesiology 4 — Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats.

Vliagoftis H. Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor J Immunol 8 —8. Galli SJ. New concepts about the mast cell. N Engl J Med 4 — Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J Immunol 8 —5. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases.

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

J Biol Chem 36 — Mast cell granules within endothelial cells: a possible signal in the inflammatory process? Mod Pathol 5 3 —7. Synthesis of 1-acylacetyl-sn-glycerophosphocholine by an enriched preparation of the human lung mast cell.

Production of interleukin-6 by human mast cells and basophilic cells. J Invest Dermatol 1 —9. Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.

Mast cells and ionizing radiation induce a synergistic expression of inflammatory genes in endothelial cells by a mechanism involving p38alpha MAP kinase and p65 NF-kappaB activation. Radiat Res 6 — Kalsner S, Richards R. Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm. Science —7. Increased adventitial mast cells in a patient with coronary spasm.

N Engl J Med 18 — Fernex M. Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries. J Pathol 1 — Endothelial cell activation by mast cell mediators.

Fernex M, Sternby NH. Mast cells and coronary heart disease. Relationship between number of mast cells in the myocardium, severity of coronary atherosclerosis and myocardial infarction in an autopsy series of cases. Acta Pathol Microbiol Scand 62 — Mast cell granules cause proliferation of human microvascular endothelial cells.

Lab Invest 55 3 — The association of mast cells and atherosclerosis: a morphologic study of early atherosclerotic lesions in young people. Hum Pathol 25 2 —9. Low density lipoprotein degradation by secretory granules of rat mast cells.

Sequential degradation of apolipoprotein B by granule chymase and carboxypeptidase A. J Biol Chem 34 — Lindstedt KA. Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells. J Biol Chem 11 —6. Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice.

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation. J Cell Biochem 3 — Barnes PJ. Histamine receptors in the lung. Agents Actions Suppl 33 — Hill SJ.

Multiple histamine receptors: properties and functional characteristics. Biochem Soc Trans 20 1 —5. J Immunol 5 — Mast cell granules inhibit macrophage-mediated lysis of mastocytoma cells P and nitric oxide production. J Leukoc Biol 53 4 — The influence of histamine on immune and inflammatory responses. Adv Immunol 35 — Histamine induces interleukin-8 secretion by endothelial cells. Blood 84 7 — Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha.

Microvasc Res 61 3 — Hough LB. Genomics meets histamine receptors: new subtypes, new receptors. Mol Pharmacol 59 3 —9. Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Science — Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells. Mol Endocrinol 22 8 — Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem 3 — New insights into the second generation antihistamines.

Drugs 61 2 — Elevation of the plasma histamine concentration in the coronary circulation in patients with variant angina. Am J Cardiol 77 12 —6.

Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I 2 and E 2 production in human coronary artery endothelial cells. J Immunol 11 — Serotonin, histamine, and norepinephrine mediation of endothelial and vascular smooth muscle cell movement. Am J Physiol 3 Pt 1 :C—7. Bell L, Madri JA. Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells.

Circ Res 65 4 — Role of histamine H1 and H2 receptor antagonists in the prevention of intimal thickening. Eur J Pharmacol 1 —9. Expression of the histamine H1 receptor gene in relation to atherosclerosis. Am J Pathol 4 —8. Histamine induces toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components. Immunology 2 — Lipopolysaccharide induces H1 receptor expression and enhances histamine responsiveness in human coronary artery endothelial cells.

Immunology 4 — PLoS One 9 7 :e Harman D. Pig atherosclerosis. Effect of the antihistamine, chlorpheniramine, on atherogenesis and serum lipids.

J Atheroscler Res 10 1 — Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins.

Arterioscler Thromb Vasc Biol 30 5 — Keywords: mast cell, immune system, inflammatory mediators, systemic hypoxia, atherogenesis. The use, distribution or reproduction in other forums is permitted, provided the original author s or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

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Dileepan 2 and John G. Introduction Mast cells are important cells of the immune system and are of the hematopoietic lineage. Location of Mast Cells Mast cells are found in mucosal and epithelial tissues throughout the body. Physiological Roles of Mast Cells Mast cells are involved in the regulation of variety of physiological functions, including vasodilation, angiogenesis, bacterial, and parasite elimination. Angiogenesis Mast cells are involved with enhancing angiogenesis Homeostasis Mast cells contribute to homeostasis in the immune system.

Innate and Adaptive Immunity Mast cells play an important role in innate and adaptive immunity. Activation and Mediator Release Mast cells upon activation release preformed and newly synthesized mediators in a phasic fashion. Get Android App. Get iOS App. Which of the following cells secretes histamine?

Solution: Mast cells are master regulators of immune r system that secrete histamine as a part of defence system against an infection. Histamine is involved, in inflammatory response released during allergy. Mast cells also secrete heparin an anticoagulant and serotonin a neurotransmitter. Questions from AMU Adjacent nucleotides are joined by a Molecular Basis of Inheritance. Bacteria protect themselves from viruses by fragmenting viral DNA upon entry with Biotechnology : Principles and Processes.

The distribution of species diversity on earth may be best described as Biodiversity and Conservation. A local histamine pool is physiologically relevant only if it is within the diffusion distance of the parietal cells, if it is effectively mobilized by gastrin, and if it is endowed with the machinery for a rapid replenishment of the histamine that has been released.

Histamine in the stomach occurs in endocrine cells so-called enterochromaffin-like ECL cells , mast cells, and neurons. The ECL cells are peptide hormone-producing cells. In mammals they are located basally in the oxyntic gland area, in the chief-cell-rich region.